The series consists of letters written by Edwards to his brothers Edward and John (the precise recipient is not usually identified) mainly from Aberystwyth and Oxford, together with some letters written from the Continent. The letters describe his experiences and activities, both academic pursuits and leisure interests, in some detail. There are many references to family news and events.

The series contains letters written by O.M. Edwards to his parents Owen and Elizabeth Edwards discussing in some detail his experiences as a student at the University of Wales, Aberystwyth, and at Balliol College, Oxford, his travels on the Continent, and his life as an Oxford don. Many of the letters contain references to events at Llanuwchllyn and to family life.