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The manuscript is in two parts. The first part is mostly in Latin and French, written c. 1584, and includes the Natura Brevium; legal proceedings from the year books of Henry VIII; the private account of a barrister; and a rental of various places in South Wales and the Marches. The second part, which is mainly in Welsh, includes texts on the British Isles and on the commotes and hundreds of Wales; Diwedd Arthur; and a charter of the Earl of Arundel, 1406.

An index to parts i and ii of Peniarth MS 139 in the autograph of William Llŷn.

An alphabetical index to the first and second lines in the first and sixth manuscripts of John Jones, Gellilyfdy, in his own hand.
The sixth manuscript is Peniarth MS 112.

An abstract of a work on music; an incomplete criticism of a theological work; extracts from a book on logic by Crellius; medical notes and recipes; and an imperfect copy of a tract, by Ja[mes] Do[w]son, on the union of England and Scotland, dedicated to James I.

A 17th century manuscript comprising various texts in Latin, namely De Scriptura; De Lege Ceremoniali; De Deo Colendo; and De Officio Christi; and notes on numerous subjects in English; poetry in Welsh; sketches of a woman carding wool and at her spinning wheel (pp. 68, 70, 76) and a sketch of a man weaving (p. 78); and texts in Welsh on astrology and dreams.
John Thomas of Rhysgog added Welsh poetry to the manuscript, c. 1765.

Correspondence and papers relating to the Montgomeryshire election (Watkin Williams v Mostyn Owen), 1774; miscellaneous transcripts, partly by Mrs Elizabeth Baker, including letters and poems of the Reverend Evan Lloyd of Fron, 1761-1768; letters of Anthony Thomas, Hendre; letters of Elizabeth Chudleigh, afterwards known as the Duchess of Kingston, 1767-1788, with notes and extracts relating to the same by Mrs Baker; and transcripts of the Lords' Protests for the session 1722-1723.

A bundle of miscellaneous papers comprising an English translation of 'ye Memorial presented in Latin to the King of Great Brittain by Monsieur Le Baron de Palm the Imperial Resident upon ye speech made by His Majesty to the two Houses of Parliament on the 17/28 of January 1726/7' (No. 1); a printed programme for a musical concert at Penbedw, 24 March 1772 (No. 2); a pedigree of the Scudamore family certified at the College of Arms, 21 March 1821 (No. 3); booksellers' bills and receipts, 19 January-5 May 1827, for books and manuscripts purchased by W. W. E. Wynne (Nos 4-7); lines composed by John Roberts on Penbedw rent day, 22 January 1829 (No. 8); a transcript by W. W. E. Wynne of 'Kywydd barddnad Lewis ab Owen' by Owain Gwynedd (No. 9); and a description by W. W. E. Wynne of the Mordaunt family vault in Twivey Church, Bedfordshire, 1832 (No. 10).

'A Breef discourse of the ordenary charge gyven to the juries at quarter sessions', 16th century.

Genealogy of the family of Williams of Cochwillan transcribed from a pedigree compiled by John Salusbury of Erbistock, and continued to the year 1722 ,18th century.

An 18th century transcript of Evelyn's Kalendarium Hortense, 1664.

'A booke of remembraunce', namely a fragment of a memoranda book of a Merioneth magistrate or attorney, with entries of law-suits, 1615.

A translation into English, with notes, of the Historia Britonum of Nennius by Robert Roberts of Hendrecoed, near Llanaber, 1782.

Miscellaneous English poetry transcribed by Mrs Elizabeth Baker.

The orders of Lieutenant-General Keppel at Coxheath camp, 1779, written by Major Watkin Williams of the Shropshire Regiment of Militia.

A facsimile manuscript in two parts mostly in the hand of William Watkin Edward Wynne. The first part comprises copies (some printed) of charters, public records, deeds, pedigrees, poetry, etc. of Merionethshire and Caernarvonshire interest, some of which are taken from transcripts made by Robert Vaughan, Hengwrt. The material includes records and pedigrees relating to the Wynn family of Peniarth; notes on the Maurice and Owen families of Clenennau, Penmorfa, Caernarvonshire, with related deeds possibly in the hand of William Maurice of Llansilin; deeds relating to the Porkington estate; an extent of the commote of Eifionydd, 1352; an extract from the Coroner's Rolls for Merionethshire, 1345; charters of Castell y Bere and Harlech Castle; pedigrees of Madog ap Dafydd of Hendwr, Llandrillo, Merionethshire; an ode to Einion ap Gruffydd of Corsygedol by Gruffudd Gryg; odes to Dafydd ab Ieuan ab Einion by Guto'r Glyn and Dafydd Nanmor; letters addressed to W. W. E. Wynne, the correspondents including Walter Davies ('Gwallter Mechain'); etc. The second part is also mostly in the hand of W. W. E. Wynne and again comprises material mainly of Merionethshire and Caernarvonshire interest, including pedigrees, correspondence, deeds, etc. relating to the Porkington estate and to the Maurice family and to the Wynne family of Glyn and Ystumcegid, Caernarvonshire; poetry relating to members of the Wynn family of Glyn by Huw Machno, Rhisiart Cynwal and others (one elegy translated into English); press cuttings taken from the Cambrian News, 1879; letters addressed to W. W. E. Wynne, the correspondents including Walter Davies ('Gwallter Mechain') and Joseph Morris; etc.

A roll of the sheriffs of Merioneth from 1538 to 1768, with the name of Rice James of Dolgelynin added in a different hand.

A list of freeholders [1670-1673]; a muster roll for Ardudwy Uchartro [Uwch Artro]; lists of presents bestowed at session; a list of soldiers in Talybont Uwchcrogen, 1644; a muster roll for Penllyn and Edeirnion, 1608; and lists of arms, men bearing unserviceable arms, and men not charged with arms in Edeirnion.

Transcripts of documents relating mainly to Merioneth: Instructions from the Council in the Marches to suppress felonies; charges to juries; a letter, with answer, to a gentleman in Wales touching suits in the Court of Star Chamber, 1598; a letter of recommendation of John Vaughan of Cair gay, 1601; a petition of the freeholders of Estymaner and Talpont; instructions to the Council in the Marches, 1606; a letter of Enianus, bishop of Bangor, to Lord John de Grey, 1310; orders for securing the peace of the Commonwealth; orders at Quarter Sessions, 1673; sentences against Hugh Nanney for incontinence, 1588, 1594; observations on tenures in Englefleld, Flintshire, and concerning a court held by Mr Mackworth; an order in the suit of Robert Lloyd v. Griffith Nanney, 1603; the opinion of George Lee concerning a Portuguese ship wrecked on the Merioneth coast, 1746; a draft petition for an Act to enclose Traeth Mawr and Traeth Bychan; a contract to erect a shire hall at Dolgelley, 1606; the divisions of Merioneth with their proportional assessments, 1689; a canvass for Mr Vaughan and a copy of R. W. Vaughan's address to Merioneth electors, 1796; a rental of Robert Morgan's estate; and the petition of Sir Robert Heath to Charles I.
Instructions to Sir William Bowes, Robert Bowes, and Lord Eure (Scottish border, 1589-1599), Sir George Carey in Ireland with the Earl of Essex, 1598, Mr Carrow Raleigh concerning musters, and Sir Thomas Shirley, Lord Sheffield, Dr Dale, and Mr Bodley (Low Countries, 1586-1598); instructions concerning the expedition to Spain, 1596; papers relating to the proposed Spanish marriage, 1623; speeches and petitions in Parliament, 1623-1626; a list of grants to the Duke of Buckingham and proceedings relating to his impeachment, 1626; and a letter by Ra: Eure, John Harbert, and Daniell Dunn from Breme, 1602.
Printed proclamations of the assumption of the style of King of Great Brittaine by James I, 1604, and of the calling in of testons, 2 Edward VI.
On the back of the former is a fragment of a Welsh poem beginning - 'a fi'n eiste'n obrydd...'

The manuscript is in two parts: The first part comprises medical recipes, mainly in English; and a rubric entitled 'Incipit compendium salernie que membris valent aut nocent'. The second part comprises a fragment of a medical treatise.

A Latin translation of the Arabic Almansor by Abu Bakr Muhammad ibn Zakariya el-Razi Rhaeses. ('Albubecri arazi filii zacarie liber incipit qui ab eo vocatus est almasor' [sic]).