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A volume, 1816 (watermark 1809), in the hand of Robert Pughe, written whilst a student at St Thomas's and Guy's Hospitals, London, containing notes of lectures on anatomy delivered mostly by Astley Cooper.
Subjects covered include the circulatory system and blood, the nervous system, muscles and bone structure (pp. 1-115), ligaments (pp. 119-135) and the brain (pp. 150-176, inverted text); there are also notes on the treatment of gonorrhoea (pp. 116-118). A contents list for the first series of lectures (pp. 1-115) is on p. 177.

A volume, [c. 1754], in the hand of Richard Pughe, surgeon and apothecary, of Machynlleth, Montgomeryshire, later of Llanegryn and Hendre, Abergynolwyn, Merioneth, containing notes on human anatomy and physiology taken mainly from William Cheselden, The Anatomy of the Humane Body, 3rd edn (London, 1726) (ff. 1-28 verso), Alexander Monro, The Anatomy of the Human Bones (Edinburgh, 1726) (ff. 29-38 verso), and from lectures delivered by William Bromfield (ff. 39-68), together with medical prescriptions (ff. 101-29 verso, inside back cover).
A short monetary account, 1816, in the hand of the surgeon's grandson Robert Pughe has been added on f. 84 verso.

A volume, 1817, in the hand of Robert Pughe, whilst a student at St Thomas's and Guy's Hospitals, London, containing notes of lectures delivered by Sir Astley Cooper on the surgical and other treatments of wounds, hernias and various illnesses.
A contents list is on pp. 355-358.

A volume, 1696-[early 18 cent.], in the hand of John Tibbots, later Vicar of Darowen, compiled mostly whilst a student at Oriel College, Oxford, containing notes and transcripts in English, Latin and Welsh on subjects including theology, church history and logic and including also several sermons.
The notes are taken from several books, including [Matthew Parker], De Antiquitate Britannicae Ecclesiae (London: J. Day, 1572, STC 19292) (f. 3); Henry Aldrich, Artis Logicae Compendium (Oxford: e Theatro Sheldoniano, 1691, Wing A896) (ff. 6-11); Jeremy Collier, Essays Upon Several Moral Subjects, Part 2 (London: R. Sare and H. Hindmarsh, 1697, Wing C5253), pp. 17, 25 (f. 23 verso); John Tillotson, Sermons Preach'd Upon Several Occasions (London, 1678, Wing T1260bA), pp. 175-200 (ff. 24-33); three sermons from The Works of the Reverend and Learned John Lightfoot D.D. (London, 1684, Wing L2051), pp. 1135-40, 1163-4, 1303-5 (ff. 33 verso-45 verso); [Simon Patrick], A Discourse of Profiting by Sermons (London: T. Basset, B. Tooke, F. Gardiner, 1683, Wing P790), pp. 2-9 (ff. 46-48); John Goodman, A Sermon Preached...at the Guild-Hall Chappel on Decemb. 18th 1681 (London: R. Royston, 1681, Wing G1126), pp. 1-33 (ff. 52-62); James Ussher, The Annals of the World (London: J. Crook and G. Bedell, 1658, Wing U149), pp. 1-2 (f. 63 recto-verso); John Tillotson, Six Sermons (London: B. Aylmer and W. Rogers, 1694, Wing T1268), pp. 247-286 (ff. 64-71 verso); [Charles Leslie], An Answer to a Book (London: [n. pub.], 1692, Wing L1120), pp. [vii]-[xxii], 1-19 (ff. 77 verso-82 verso); [Francis Gastrell], Some considerations concerning the Trinity (London: E. Whitlock, 1696, Wing G303), pp. 1-12 (ff. 83-86 verso); [Louis Jobert], The Knowledge of Medals (London: William Rogers, 1697, Wing J755), pp. 1-5 (ff. 88-89 verso); and John Wagstaffe, The Question of Witchcraft Debated (London: Edward Millington, 1669, Wing 198), pp. 4-15 (ff. 90-91). The single text in Welsh is a short homily to be read to repenting adulterers, entitled 'Coffaad bur neu Ddarn o rybydh i dorwyr priodas a godinebwyr...', apparently unpublished (ff. 74 verso-77). A short memorandum concerning butter, [1792], is on f. 2 verso.

Student notebooks, 1696-1817, of members of the Pughe family, consisting of John Tibbots' lecture notes on theology, 1696-[early 18 cent.], Richard Pughe's lecture notes on anatomy, [c. 1754], and Robert Pughe's lecture notes on anatomy and surgery, 1816-1817.