A sixteenth-century manuscript containing a medical treatise in Welsh, recipes, charms, and an astrological fragment; a treatise on uroscopy in English; poetry, including a cywydd by Ieuan Brydydd Hir (hynaf); 'Llythyr Aresdotlys [...] o gadwedigaeth korff dyn ac gavas ynte yn hemyl yr havl [...]' (pp. 228-237); and a prologue to a work which is called 'Compod' ('o herwydd I vod ef yn comprehendio [...] kompod Manuwel') (pp. 197-200).
The manuscript is written in several hands of the early to late sixteenth century, possibly including that of its original owner Bened ap Rhys (Bened Feddyg) of Llanelidan, Dyffryn Clwyd, as well as Tudur ab Elise (see p. 150).